Terry Snell, an Emeritus Professor in the School of Biological Sciences, is a member of the Parker H. Petit Institute for Bioengineering and Bioscience.

My laboratory investigates molecular mechanisms underlying eukaryotic genome stability. Chromosomal rearrangements create genetic variation that can have deleterious or advantageous consequences. Karyotypic abnormalities are a hallmark of many tumors and hereditary diseases in humans. Chromosome rearrangements can also be a part of the programmed genetic modifications during cellular differentiation and development. In addition, gross DNA rearrangements play a major role in the chromosome evolution of eukaryotic organisms. Therefore, elucidation of molecular mechanisms leading to chromosome instability is important for studying human pathology and also for our understanding of the fundamental processes that determine the architecture and dynamics of eukaryotic genomes. 

My overall contribution to the field of genome instability has been the demonstration of the phenomenon that repeats often found in eukaryotic genomes are potent sources of genome instability. Specifically, I have been investigating one of the most fundamental and enigmatic processes as to how repetitive sequences that adopt non-canonical DNA secondary structures, such as hairpins and cruciforms, cause replication arrest, double-strand breaks, and gross chromosomal rearrangements. Using molecular biology approaches, we investigate the instability of secondary structure-forming repeats in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and human fibroblasts.

Roman Mezencev is an adjunct associate professor in the School of Biological Sciences at Georgia Tech and a scientist at the U.S. EPA’s National Center of Public Health and Environmental Assessment. His areas of research interest include cancer biology, pharmacology, toxicogenomics, protein misfolding diseases, and public health. In cancer biology, his main research focuses on using omics data to identify new cancer subtypes through molecular profiling, which can help enhance their diagnosis and treatment. Additionally, Mezencev explores the use of omics data to predict and understand chemically-induced cancer and other adverse outcomes to protect public health. He is also investigating the intriguing epidemiological associations and mechanistic connections between cancer and Alzheimer’s disease (AD), as well as other protein-misfolding diseases. By understanding these associations, we can identify shared risk factors and molecular mechanisms that can lead to the development of new anti-cancer and anti-AD drugs and enhance our understanding of these complex diseases.
 

King Jordan is Professor in the School of Biological Sciences and Director of the Bioinformatics Graduate Program at the Georgia Institute of Technology. He has a computational laboratory and his group works on a wide variety of research and development projects related to: (1) human clinical & population genomics, (2) computational genomics for public health, and (3) computational approaches to functional genomics. He is particularly interested in the relationship between human genetic ancestry and health. His lab is also actively engaged in capacity building efforts in genomics and bioinformatics in Latin America. 

Dr. Kostka is currently a professor of Biology at Georgia Institute of Technology (GT). Prior to GT, he was an Associate Professor at the Department of Oceanography, Florida State University. His research involves microorganism studies in geochemical cycles of pristine and contaminated ecosystems, from the oceans to the terrestrial subsurface.

Jennifer Leavey is a principal academic professional in the School of Biological Sciences and assistant dean for Faculty Mentoring for the College of Sciences. She also coordinates the College's educational programs related to science and sustainability including the Georgia Tech Urban Honey Bee Project and the Living Building Science Vertically Integrated Project Team.   

Katherine Duchesneau is a Ph.D. student in the School of Biological Sciences at Georgia Tech. Her dissertation research closely couples biogeochemistry with metagenomics to elucidate the impacts of climate change on soil microbial communities that play an important role in greenhouse gas production and the global carbon cycle. Over the long term, she plans to pursue a career in academia, generating fundamental research that drives the development of climate change mitigation and adaptation strategies. Katherine strongly believes that substantive solutions for sustainability issues will only be achieved through multi-disciplinary and diverse collaborations that bring together scientists, policymakers, and the public. Before coming to Georgia Tech, Katherine completed a MSc at Queen’s University with Dr. Robert Colautti and Dr. Pedro Antunes researching the effects of Alliaria petiolata invasion on soil microbial communities. She also holds a bachelor’s degree in Environmental Biology, specializing in plant biology, from McGill University.

Matt is a former Tar Heel from UNC Chapel Hill. His training is in mass spectrometry-based proteomics and G protein signaling. He has been investigating PTMs since 2001. He is also a co-director of the Systems Mass Spectrometry Core (SYMS-C) facility at Georgia Tech.