Selected recent publications:
➤ Robert G. Mannino, Eric J. Nehl, Sarah Farmer, Amanda Foster Peagler, Maren C. Parsell, Viviana Claveria, David Ku, David S. Gottfried, Hang Chen, Wilbur A. Lam, and Oliver Brand, “The critical role of engineering in the rapid development of COVID-19 diagnostics: Lessons from the RADx Tech Test Verification Core” Science Advances. 9, eade4962 (2023). https://www.science.org/doi/10.1126/sciadv.ade4962
➤ Liu ZL, Bresette C, Aidun CK, Ku DN. (2021) SIPA in 10 milliseconds: VWF tentacles agglomerate and capture platelets under high shear. Blood Advances doi.org/10.1182/bloodadvances.2021005692
➤ Kim DJ, Ku DN. “Structure of shear-induced platelet aggregated clot formed in an in vitro arterial thrombosis model” Blood Adv (2022) 6 (9): 2872–2883. doi.org/10.1182/bloodadvances.2021006248
➤ Kim DJ, Bressette C, Liu Z, Ku DN. Occlusive thrombosis in arteries. APL Bioengineering 2019;3, 041502. https://doi.org/10.1063/1.5115554
Licensed Patents:
➤ Ku, D.N., Wootton, D.M., Greer-Braddon, L., “Poly(vinyl Alcohol) Cryogel,” No. 5,981,826 and 6,231,605, issued May 15, 2001. Licensed; created prosthetic cartilage; acquired by Wright Medical. $645 million
➤ Denoziere, G., Ku, D.N., “Methods of Producing PVA Hydrogel Implants and Related Devices,” issued U.S. Patent No. 8,038,920, Licensed to Mimedx. Market cap >$600 million.
Lawrence P. Huang Chair in Engineering and Entrepreneurship
Additional Research
New Project: Lysis of platelet clots to treat heart attacksBackground: Heart attacks and strokes come from a sudden thrombosis or accumulation of platelets in an artery.Our Findings: Our group has discovered the biophysical reason for this sudden occlusion and multiple points of therapy to prevent or dissolve the platelet-rich clot. Current Objectives: Quantify the architecture and strength of the thrombus to prevent or dissolve the thrombus using nano-devices and synthetic proteins.
